Panajachel is packed with hotels, small restaurants, lively nightspots and has several schools to learn Spanish. It has been overwhelmed in recent years by tourists, with souvenir shops and stalls lining the main street (Calle Santander). Significantly, the town does offer several features of eco-cultural interest.

The restored 16th century Catholic church, San Francisco Assis is the enduring feature of a Franciscan mission established here to Christianize the indigenous population on the north shore. Its stone faced, stepped-up facade is unique. Of more contemporary interest are the Museo Lacustre Atitlan on downtown Avenida Santander and two ecological/cultural attractions on the edge of town, The San Buenaventura Nature Reserve and Centro Cultural Los Encuentros.

The Museo Lacustre houses a professionally organized collection of rare archeological artifacts recovered from the Lake's bed. The Nature Reserve is an extensive tract dedicated to the preservation of flora and fauna native to the Lake basin eco-system.

Los Encuentros is a relatively small, private center dedicated to the promotion of local Mayan culture. It holds the most extensive tutorial medicinal plant garden in the Lake Atitlan Basin and a modest gallery which showcases the variety of styles employed by indigenous artists of the Lake. The staff of the center also facilitates encounters with indigenous shamans, painters, and weavers in their own settings.